陳舜華｜CHEN,SHUN HUA

師資陣容

陳舜華｜CHEN,SHUN HUA

🎓　學士後護理系專任助理教授兼國際專修部主任

👨‍🎓　長庚大學生物醫學研究所生理藥理組博士

📞　07-7811151 轉2402／7024

📧　FT104@fy.edu.tw

📖　學術專長

腫瘤分子生物學(腫瘤標記/liquid biopsy)、腫瘤護理學、藥理學、生理學、病理學

學歷

長庚大學生物醫學研究所生理藥理組博士

經歷

林口長庚醫院血液腫瘤科護理師
和信治癌中心醫院血液腫瘤科護理師
林口長庚婦癌研究中心博士後研究員
長庚大學生物醫學研究所博士後研究員

學術專長

腫瘤分子生物學(腫瘤標記/liquid biopsy)
腫瘤護理學
藥理學
生理學
病理學

開設課程

生理學
藥理學
病理學
內外科護理學
專題報告研討
內外科護理OSCE

專題/論文指導

證照

中華民國護理師執照
中華民國護士執照
美國紐約州護理師執照
Level One Program of National Association for Holistic Aromatherapy (No. NAHA-AZ-22-029), NAHA APPROVED SCHOOL EDUCATOR。

期刊論文

Chen SH, Lin HC, Yeh SA, Chen CH, Hwang TL, and Chen PJ. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis. Journal of Advanced Research, 2024 May; pending (IF: 10.7; Rank: 10/73 (13.7%), Multidisciplinary Sciences)
el-Rahman YAA, Chen PJ, ElHady AK, Chen SH, Lin HC, El-Gamil DS, Aboushady Y, Abadi1 AH, Abdel-Halim M, Engel M. Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity. Future Medicinal Chemistry, 2024 Apr; acceptance (IF: 4.2; Rank: 21/60 (35%), Chemistry, Medicinal)
Chen PJ, Chen SH, Chen YL, Wang YH, Lin CY, Chen CH, Tsai YF, and Hwang TL. Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome. Journal of Advanced Research, 2024 Mar; S2090-1232(24)00119-X (IF: 10.7; Rank: 10/73 (13.7%), Multidisciplinary Sciences)
Chen SH, Chen PJ, Lee CH, Wu YP, Ahorsu DS, Griffiths M, Lin CY. Perceived stress mediating the association between mindfulness and resilience among registered nurses. Psychology Research and Behavior Management, 2023 Aug; 16:3035-3044 (SSCI; IF: 4.3; Rank: 29/147 Q1; Psychology, Multidisciplinary)
Chen PJ, Tseng HH, Wang YH, Fang SY, Chen SH, Chen CH, Tsai SC, Chang YC, Tsai YF, and Hwang TL. Palbociclib blocks neutrophilic PI3K activity to alleviate psoriasiform dermatitis. British Journal of Pharmacology, 2023 Aug; 180(16):2172-88 (IF: 7.3; Rank: 25/277 Q1, Pharmacology & Pharmacy)
Wagdy R, Chen PJ, Hamed MM, Darwish SS, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, and Engel M. From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors. Bioorganic Chemistry, 2022 Oct; 127, 105977. (IF: 5.1; Rank: 7/52 Q1, Chemistry, Organic)
Tseng HJ, Kuo LM, Chen PJ, Chen SH, Liu CJ, Chien SY, Tsai YC, Wu YJ, Su TR, Sung PJ. Chlorofurancembranoids A and B: Novel cembranoids from octocoral Sinularia sp. Tetrahedron, 2022 Jul; 119, 132851. (SCI, IF: 2.1; Rank: 28/52 Q3, Chemistry, Organic)
Zeng JS, Wu TY, Chen PJ, Chi WC, Chen NF, Wu YC, Fang LS, Chen SH*, Kuo LM, Sung PJ. Coniferains C and D, new eunicellin-based diterpenoids from Cladiella conifera. Heterocycles, 2022 Jun. 104(8), 1461 (SCI; IF: 0.6; Rank: 49/52 Q4, Chemistry, Organic) *通訊作者
Darwish SS, Chen PJ, Hamed MM, Wagdy R, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, and Engel M. Development of (4-phenylamino)quinazoline alkylthiourea derivatives as novel NF-κB inhibitors. Pharmaceuticals, 2022 Jun; 15(7), 778. (IF: 4.6; Rank: 72/277 Q2, Pharmacology & Pharmacy)
Zeng JS, Tseng CC, Tsai YC, Chen SH, Chen PJ, Chen NF, Wen ZH, Hwang TL, Sung PJ. Coniferains A and B, new eunicellin-based diterpenoids from the octocoral Cladiella conifera (Tixier-Durivault, 1943). Phytochemistry Letters, 2022 June; 49:88-92. (SCI, IF: 1.7; Rank: 143/238 Q2, Plant Sciences)
Chao A, Liao ML, Chen SH, Lee YS, Tsai CN, Lin CY, Tsai CL. JAK2-mediated phosphorylation of stress-induced phosphoprotein-1 is critical for sustaining the JAK2/STAT3 signaling pathway in cancer cells. International Journal of Molecular Sciences, 2022 Feb; 23(5):2420 (SCI, IF: 5.6; Rank: 66/285 Q1, Biochemistry & Molecular Biology)
Lin CY, Alimoradi Z, Ehsani N, Ohayon MM, Chen SH*, Griffiths MD, Pakpour AH*. Suicidal ideation during COVID-19 pandemic among a large-scale Iranian sample: The roles of generalized trust, insomnia, and fear of COVID-19. Healthcare, 2022 Jan; 10:93 (SSCI; IF: 2.8; Rank: 43/87 Q2, Health Policy & Services) *通訊作者
Pakpour AH, Lin CK, Safdari M, Lin CY, Chen SH*, Hamilton K*. Using an integrated social cognition model to explain green purchase behavior among adolescents. International Journal of Environmental Research and Public Health, 2021 Dec; 18:12633 (SSCI; IF: 4.614; Rank: 45/182 Q1, Public, Environmental & Occupational Health) *通訊作者
Zeng JS#, Chen SH#, Lo YH, Chen NF, Wen ZH, Chen JJ, Liaw CC, and Sung PJ. A New Natural Butenolide, (5R)-3-tetradecyl-5-methyl-2(5H)-furanone, from Octocoral Cladiella Conifera. Heterocycles, 2021 Nov; 104. (SCI; IF: 0.6; Rank: 49/52 Q4, Chemistry, Organic) #共同第一作者
Lin CY#, Chen SH#, Tsai CL, Tang YH, Wu KY, Chao A. Intracellular targeting of STIP1 inhibits human cancer cell line growth. Translational Cancer Research, 2021 Jan; 10(3):1313-1323. (SCI; IF: 0.9; Rank: 235/241 Q4, Oncology) #共同第一作者
Chen SH, Chao A, Tsai CL, Sue SC, Lin CY, Lee YZ, Hung YL, Chao AS, Cheng AJ, Wang HS, Wang TH. Utilization of HEPES for enhancing protein transfection into mammalian cells. Molecular Therapy - Methods & Clinical Development, 2019 Jun; 13:99-111. (SCI; IF: 4.7; Rank: 54/136 Q2, Medicine, Research & Experimental)
Wang HS, Tsai CL, Chang PY, Chao A, Wu RC, Chen SH, Wang CJ, Yen CF, Lee YS, Wang TH. Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. PLoS One, 2018 Jan; 13(1):e0190573. (SCI, IF: 3.7; Rank: 26/73 Q2, Multidisciplinary Sciences)
Tsai CL, Chao A, Jung SM, Tsai CN, Lin CY, Chen SH, Sue SC, Wang TH, Wang HS, Lai CH. Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells. Oncotarget, 2016 Aug; 7(31):50548-50563. (SCI, IF: 5.168; Rank: 44/217 Q1, Oncology)
Chao A, Tsai CL, Jung SM, Chuang WC, Kao C, Hsu A, Chen SH, Lin CY, Lee YC, Lee YS, Wang TH, Wang HS, Lai CH. BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a Potential Biomarker in Ovarian Cancer. PLoS One, 2015 Jul; 10(7):e0133081. (SCI, IF: 3.7; Rank: 26/73 Q2, Multidisciplinary Sciences)
Wang TH, Chao A, Tsai CL, Chang CL, Chen SH, Lee YS, Chen JK, Lin YJ, Chang PY, Wang CJ, Chao AS, Chang SD, Chang TC, Lai CH, Wang HS. Stress-induced Phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation. Molecular & Cellular Proteomics, 2010 May; 9(9):1873-84. (SCI, IF: 7.0; Rank: 5/77 Q1, Biochemical Research Methods)

研討會論文

Tsai SC, Chen SH, Chen PJ, and Hwang TL. CDK inhibitor serves as a new drug for treatment of neutrophilic psoriasiform dermatitis. 第36屆生物醫學聯合學術年會, 2022 (永信李天德醫藥基金會壁報論文獎優等獎)

會議論文

Tsai SC#, Chen SH#, Lam SH, Lee CH, Chen PJ. A selective ferroptosis inducer from Pholidota exerts anticancer ability in the treatment of colorectal cancer. 第38屆天然藥物研討會, 2023 (#共同第一作者)
Chen PJ, Chen SH, and Hwang TL. Drug repurposing of ribociclib in the treatment of inflammatory disease. The 19th World Congress of Basic and Clinical Pharmacology, Glasgow, UK, 2023
Chen SH, Chang YC, and Chen PJ. The ROS-dependent effects of Aaptos-derived natural components in the treatment of colorectal cancer. 第37屆生物醫學聯合學術年會, 2023
Chen PJ, Chen SH, Sie JY, and Hwang TL. The effects of a pure compound from Bletilla in the treatment of acute liver injury. 第37屆生物醫學聯合學術年會, 2023
Tsai SC, Chen SH, Chen PJ, and Hwang TL. CDK inhibitor serves as a new drug for treatment of neutrophilic psoriasiform dermatitis. 第36屆生物醫學聯合學術年會, 2022 (永信李天德醫藥基金會壁報論文獎優等獎)
Chen PJ, Chen SH, Tseng HH, and Hwang TL. CDK inhibitor ameliorates neutrophil-associated psoriasiform dermatitis by inhibiting PI3K activity. 14th Asia Pacific Federation of Pharmacologists, Pharmacological Society in Taiwan, Taiwan, 2021

研究計畫

陳舜華 (主持人), 壓力誘導磷酸蛋白1調控卵巢癌免疫微環境之研究 (110-2314-B-242-003), 國科會, 2021/08/01-2022/07/31
陳舜華 (共同主持人), 探討肺炎克雷伯氏菌引發嗜中性白血球N2極化作用的機制 (EDCHP113006), 義大醫院, 2024/02/01-2025/01/31
陳舜華 (共同主持人), 從蘭科植物開發鐵依賴性死亡誘導劑用以治療大腸直腸癌之臨床前研究 (EDCHP113002), 義大醫院, 2024/02/01-2025/01/31
陳舜華 (共同主持人), 海洋海綿天然成份用於治療大腸直腸癌之臨床前研究 (EDCHP112011), 義大醫院, 2023/01/01-2023/12/31

專利

Angel Chao, Tzu-Hao Wang, Shun-Hua Chen. Novel protein transfection compositions and uses thereof. Patent No.: 3360564; Date: 12.06.20 (European: Germany, UK, and France)
Tzu-Hao Wang, Shun-Hua Chen. Stress-induced phosphoprotein 1 as a biomarker for the detection of human ovarian cancers and endometriosis. Patent No.: US 7, 851,230B2; Date of Patent: Dec. 14, 2010.

榮譽事蹟

Editorial board member, Academic Reads Journal of Case Reports, 2021-present
Tsai SC, Chen SH, Chen PJ, and Hwang TL. CDK inhibitor serves as a new drug for treatment of neutrophilic psoriasiform dermatitis. 第36屆生物醫學聯合學術年會, 2022 (永信李天德醫藥基金會壁報論文獎優等獎)

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